TAG HIV Basic Science, Vaccines, and Cure Project Blog
By Richard Jefferys, Project Director at Treatment Action Group (TAG).
recent posts
- In The News: CAR-T Cells for HIV
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the March 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the February 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the December 2025 and January 2026 Updates
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the November 2025 Update
Category: HIV-specific T cell immunity
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For August 2025, there were eight updates to the TAG listing. New Additions A study sponsored by the ANRS RHIVIERA project in France plans to investigate the JAK1/JAK2 Inhibitor baricitinib and the mTOR Inhibitor sirolimus in people who started antiretroviral therapy (ART) soon after HIV acquisition. Baricitinib is also being tested in several other ongoing…
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The were ten updates to the TAG listing in July 2025. New Additions Four newly registered HIV cure-related studies were added: Oxford University in the UK is sponsoring AbVax, a phase II combination trial that will administer therapeutic vaccines designed to induce T cell responses against HIV plus two broadly neutralizing antibodies (bNAbs), teropavimab…
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The June 2025 update to TAG’s listing features 11 changes. New Additions Two studies were added: The ACTG has registered a new trial of dual broadly neutralizing antibodies (bNAbs), VRC07-523LS and PGT121.414.LS, in people who initiated antiretroviral therapy (ART) during acute HIV infection. The protocol includes an analytical treatment interruption (ATI) to assess whether receipt…
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For November 2024, there were 11 updates to TAG’s listing. We’ve also added the country locations for each of the current trials (previously, site locations were only included in the table in our annual Research Toward a Cure and Immune-Based Therapies Pipeline Report). New Additions Four new clinical trials were identified in registries: Researchers in…
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There were 14 updates to TAG’s listing for October 2024. New Additions Two new clinical trials were identified in registries, neither yet open for enrollment: Researchers in the UK are initiating a study of the anti-CMV drug letermovir primarily to assess effects on T cell activation in people with HIV on antiretroviral therapy (ART). Markers…
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Last month’s revision to TAG’s listing included ten updates. New Additions There was only one new HIV cure-related trial identified in registries. The protocol, named Tatelo Plus, represents a follow up to a prior smaller evaluation of dual broadly neutralizing antibodies (bNAbs) in children with HIV in Botswana (the Tatelo study). The research project is…
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There are seven updates in the July 2024 revision to TAG’s listing. New Additions Only one new cure-related clinical trial was identified in registries over the past month, which is a revised version of a protocol that was previously withdrawn. The study is sponsored by the US Military HIV Research Program (MHRP), and will assess…
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No new HIV cure-related trials or studies have been added to the clinicaltrials.gov registry over the past month. Two trials in the listing have changed status: A study sponsored by the ANRS in France investigating the link between specific immune system genetics (MHC B35/53Bw4TTC2) and post-treatment control of HIV is now open for enrollment. Participants…
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The April 2023 update to TAG’s HIV cure-related clinical research listing adds five new studies, two involving interventions and three observational. Researchers at the University of Sao Paulo General Hospital in Brazil are opening a study of a therapeutic HIV vaccine based on dendritic cells (DCs). DCs are immune system cells tasked with initiating the…
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This year’s virtual Conference on Retroviruses and Opportunistic Infections (CROI) ended on February 24th. Abstracts from the meeting are now available publicly in an abstract book and searchable database. Webcasts of all the presentations are due to become available around March 25th. Several presenters reported potentially encouraging developments in HIV cure research, in addition to…