TAG HIV Basic Science, Vaccines, and Cure Project Blog
By Richard Jefferys, Project Director at Treatment Action Group (TAG).
recent posts
- In The News: CAR-T Cells for HIV
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the March 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the February 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the December 2025 and January 2026 Updates
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the November 2025 Update
Category: Latency reversing agents
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The were ten updates to the TAG listing in July 2025. New Additions Four newly registered HIV cure-related studies were added: Oxford University in the UK is sponsoring AbVax, a phase II combination trial that will administer therapeutic vaccines designed to induce T cell responses against HIV plus two broadly neutralizing antibodies (bNAbs), teropavimab…
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For September 2024 there are six updates to TAG’s listing: New Additions One new study was registered over the past month, a protocol for conducting analytical treatment interruptions (ATIs) in people with HIV who’ve received successful stem transplants to treat cancers. The criteria require that the stem cell transplants were sourced from donors homozygous for…
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There are ten updates in the May 2024 revision to TAG’s listing. No new HIV cure-related clinical trials or observational studies were identified in registries this month, and one protocol was withdrawn: a combination study codenamed RV582 sponsored by the US Military HIV Research Program (MHRP). No explanation for the withdrawal is provided in the…
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The March 2024 revision to TAG’s listing includes 26 updates. The annual Conference on Retroviruses and Opportunistic Infections (CROI) took place in Denver from March 3-6, and the addition of links to results from HIV cure-related studies presented at the meeting typically makes this the busiest month for changes — hence the delay to this…
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A total of nine changes were made to TAG’s listing for the February 2024 update. New Additions Two new clinical trials have been added, both not yet open for enrollment. Researchers at the City of Hope Medical Center in Los Angeles are planning to initiate a trial of a novel approach to chimeric antigen receptor…
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There are ten updates this month: a newly entered therapeutic HIV vaccine trial in China, a new observational study in Belgium, one observational study shifted to the completed studies table, and links added to presented/published results for seven of the studies in the listing. The therapeutic HIV vaccine trial is testing a novel DNA construct…
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The past month has seen relatively few updates for TAG’s HIV cure-related clinical research listing. One new observational study was entered into the clinicaltrials.gov registry, two trials have been completed or ended, an ongoing investigation of the anti-CMV drug letermovir has reopened for enrollment after a pre-planned pause, and a social science assessment of factors…
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The April 2023 update to TAG’s HIV cure-related clinical research listing adds five new studies, two involving interventions and three observational. Researchers at the University of Sao Paulo General Hospital in Brazil are opening a study of a therapeutic HIV vaccine based on dendritic cells (DCs). DCs are immune system cells tasked with initiating the…
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The February 15, 2023 update to TAG’s HIV cure-related clinical research listing includes three newly registered studies: The AIDS Clinical Trials Group (ACTG) is initiating a study of two long-acting broadly neutralizing antibodies (bNAbs) named VRC07-523LS and PGT121.414.LS combined with antiretroviral therapy (ART) in people with acute (recently acquired) HIV infection. The trial has yet…
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The Conference on Retroviruses and Opportunistic Infections (CROI) is taking place virtually again this year, running from February 12th to February 24th. In a session today on HIV cure research, Yvonne Bryson and colleagues from the IMPAACT research network presented important news about another potential example of an HIV cure achieved by stem cell transplantation.…