TAG HIV Basic Science, Vaccines, and Cure Project Blog
By Richard Jefferys, Project Director at Treatment Action Group (TAG).
recent posts
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the February 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the December 2025 and January 2026 Updates
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the November 2025 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the October 2025 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the September 2025 Update
Category: TB
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The annual Conference on Retroviruses & Opportunistic Infections (CROI) took place in Seattle from February 13th-16th, offering a dizzying parade of new data. Webcasts of presentations and PDF files of posters were rapidly placed online and are accessible via the CROI website. A Fillip for Kick & Kill On the cure research front, the results…
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Two recent papers suggest that limitations on the activation of TB-specific CD4 T cells may contribute to the persistence of the infection. In PLoS Pathogens, Tyler Bold and colleagues show that only a small percentage of CD4 T cells targeting TB’s Ag85B peptide 25 produce the cytokine interferon gamma in the lungs of infected mice.…
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In a new paper published yesterday by Nature Medicine, researchers from the Statens Serum Institut (SSI) in Denmark describe encouraging results obtained with a new TB vaccine candidate. The design of the vaccine was informed by data showing that a particular TB protein, Rv2660c, remains strongly expressed during latent infection. This knowledge prompted the development…
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Active tuberculosis in the pre-antibiotic era had a grim prognosis, but around 50% of people who developed pulmonary disease were able to recover (albeit typically after a prolonged convalescence). In a newly published study from the UK, researchers identify 27 individuals aged 66-91 years old who survived pulmonary TB prior to the availability of treatment,…
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As eloquently described by Javid Syed in a chapter of TAG’s recent pipeline report, TB diagnostics remain woefully inadequate for addressing the challenges presented by the disease. One key goal for scientists is to find ways to better discriminate active from latent infection, and two recent papers describe possible progress in this effort. In the journal…
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Following up on a prior post about the link between loss of T cell responses to tuberculosis and reactivation TB disease, a new paper in the Journal of Immunology reports on the functionality of TB-specific T cell responses before and after antiretroviral treatment (ART). The study – led by Jayne S. Sutherland from the Medical…