TAG HIV Basic Science, Vaccines, and Cure Project Blog
By Richard Jefferys, Project Director at Treatment Action Group (TAG).
recent posts
- In The News: CAR-T Cells for HIV
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the March 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the February 2026 Update
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the December 2025 and January 2026 Updates
- TAG’s HIV Cure-Related Clinical Research Listing: Background on the November 2025 Update
Category: Therapeutic vaccines
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There are 14 updates in the June 2024 revision to TAG’s listing. New Additions Three newly registered studies have been added: two interventional and one observational. The German company Hookipa Biotech is sponsoring a clinical trial assessing two therapeutic HIV vaccine candidates based on an arenavirus vector platform in people with HIV on antiretroviral…
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There are ten updates in the May 2024 revision to TAG’s listing. No new HIV cure-related clinical trials or observational studies were identified in registries this month, and one protocol was withdrawn: a combination study codenamed RV582 sponsored by the US Military HIV Research Program (MHRP). No explanation for the withdrawal is provided in the…
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The April 2024 update to TAG’s listing features eight changes. New Additions Three new studies were added this month. All are protocols being initiated by the U.S. government-funded ACTG Network (formerly known as the AIDS Clinical Trials Group, recently revised to Advancing Clinical Therapeutics Globally). The Antiretrovirals Combined With Antibodies for HIV-1 Cure In Africa…
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The March 2024 revision to TAG’s listing includes 26 updates. The annual Conference on Retroviruses and Opportunistic Infections (CROI) took place in Denver from March 3-6, and the addition of links to results from HIV cure-related studies presented at the meeting typically makes this the busiest month for changes — hence the delay to this…
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A total of eight changes were made to TAG’s listing for the first monthly update of 2024. New Additions One new study has been added from the Pan African Clinical Trials Registry: Scientists affiliated with the Centre for the AIDS Programme of Research in South Africa (CAPRISA) are launching a phase I cure-related trial investigating…
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No new HIV cure-related trials or studies have been added to the clinicaltrials.gov registry over the past month. Two trials in the listing have changed status: A study sponsored by the ANRS in France investigating the link between specific immune system genetics (MHC B35/53Bw4TTC2) and post-treatment control of HIV is now open for enrollment. Participants…
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There are ten updates this month: a newly entered therapeutic HIV vaccine trial in China, a new observational study in Belgium, one observational study shifted to the completed studies table, and links added to presented/published results for seven of the studies in the listing. The therapeutic HIV vaccine trial is testing a novel DNA construct…
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The April 2023 update to TAG’s HIV cure-related clinical research listing adds five new studies, two involving interventions and three observational. Researchers at the University of Sao Paulo General Hospital in Brazil are opening a study of a therapeutic HIV vaccine based on dendritic cells (DCs). DCs are immune system cells tasked with initiating the…
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March tends to be the busiest month for updates to TAG’s HIV cure-related clinical research listing because of results being presented at the annual Conference on Retroviruses and Opportunistic Infections (CROI). Today’s update includes links to 30 abstracts from CROI 2023; posters can be downloaded from the abstract pages, but webcasts of oral presentations won’t…
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One of the most widely discussed and publicized ideas for targeting the HIV reservoir is “kick and kill” or “shock and kill.” The aim is to kick dormant, latent HIV into revealing itself so the cells that contain the virus are visible to the immune system; the kill aspect involves trying to enhance the immune…