Category: Gene therapy
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Since the previous update on May 16, there have only been two changes identified for TAG’s HIV cure-related clinical research listing, making it one of the quietest periods since the initiation of the resource in 2014. A small clinical trial sponsored by the AIDS Malignancy Consortium investigating gene-modified stem cells for people with HIV and…
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The April 2023 update to TAG’s HIV cure-related clinical research listing adds five new studies, two involving interventions and three observational. Researchers at the University of Sao Paulo General Hospital in Brazil are opening a study of a therapeutic HIV vaccine based on dendritic cells (DCs). DCs are immune system cells tasked with initiating the…
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This year’s virtual Conference on Retroviruses and Opportunistic Infections (CROI) ended on February 24th. Abstracts from the meeting are now available publicly in an abstract book and searchable database. Webcasts of all the presentations are due to become available around March 25th. Several presenters reported potentially encouraging developments in HIV cure research, in addition to…
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The past year has seen a notable expansion of efforts to apply gene therapy approaches to HIV cure research, and several online events have highlighted progress in the field. In parallel, work is underway that aims to make gene therapies more affordable and accessible globally. Two papers published early in the year (one in the…
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One of the most widely discussed and publicized ideas for targeting the HIV reservoir is “kick and kill” or “shock and kill.” The aim is to kick dormant, latent HIV into revealing itself so the cells that contain the virus are visible to the immune system; the kill aspect involves trying to enhance the immune…
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A number of conferences and workshops related to HIV cure research have taken place over the past several months, many of which can be viewed or learned about online. Links and some brief reports from four events are provided below. Promising Approaches to HIV Remission and Cure HIV cure research was the chosen topic for…
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In June of this year, a short paper was published in the journal Nature Medicine reporting that individuals homozygous for the CCR5-∆32 mutation showed a 21% increase in the rate of all-cause mortality compared to those without the mutation (or heterozygotes, who inherit the mutation from one parent). The senior author, Rasmus Nielsen, stated to the Wall…
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The 2019 Conference on Retroviruses and Opportunistic Infections (CROI) took place in Seattle from March 3rd-7th. The major news on the cure research front was the possibility of two additional cases similar to Timothy Ray Brown, who for the past 12 years has been the only individual considered cured of HIV infection (TAG issued a…
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Several recently presented and published studies offer potentially important new data relevant to efforts to identify cells containing latent HIV and target them for elimination. At the 8th International Workshop on HIV Persistence held in Miami last December, multiple research groups reported on their attempts to confirm a newly published—and widely publicized—claim that the cell surface molecule CD32a…
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The IAS HIV Cure & Cancer Forum was held at the renowned cancer research center Institut Curie in Paris on July 22 & 23 of this year. A report from the meeting, authored by Genevieve E. Martin, José Alcami, Jean-Phillipe Spano and Anna Laura Ross, has just been published in the open access Journal of Virus…