The July issue of the journal Cytometry Part A contains an
excellent article by Pratip Chattopadhyay and Mario Roederer reviewing the use
of flow cytometry to study T cell subsets in HIV infection. The
entire journal issue is free access.
Cytometry Part A
Special Issue: CYTOMETRY – 30th Anniversary 1980 – 2010
Volume 77A, Issue 7, pages 614–622, July 2010
DOI: 10.1002/cyto.a.20905
Review Article
Good cell, bad cell: Flow cytometry reveals T-cell subsets
important in HIV disease
Pratip K. Chattopadhyay, Mario Roederer
Abstract
Flow cytometry is a key technology in the study of HIV
disease. In this article, we review various cellular markers that can be
measured in the setting of pathogenesis or vaccination studies, including
markers of activation, differentiation, senescence, immune suppression, and
function. In addition, we discuss important considerations for making these
measurements. Finally, we examine how flow cytometry studies have taught
researchers about the disease process, and the potential for flow cytometry
technology to guide treatment decisions and evaluate vaccine candidates in the
future.
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